about 70 y old patient; a severe lyphoma is known with condition after several chemotherapies, but there is still a progress of lymphoma. Actually the patient was admitted to our ICU with deep hypotension and the clinical and laboratory cirterias of septic shock; focus of infection was pluriseptal pleural empyema an both sides. Notwithstandig therapy with calculated antibiotics, volume, catecholamines, pirtessin and continuous veno-venous haemofiltration we couldn´t rescue the patient. In TEE we found no sign for endocarditis and a hyperdynamic left and right ventricle. Besides we could see infiltration of lymphoma.